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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1984-4-24
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pubmed:databankReference |
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pubmed:abstractText |
The nucleotide sequence of the human T-cell leukemia virus type II (HTLV-II) long terminal repeat (LTR) and its surrounding regions were determined. Our results show the following structural features: (i) the LTR is 763 base pairs (bp) in length and consists of 314 +/- 1 bp of region U3, 248 +/- 1 bp of region R, and 201 bp of region U5; (ii) the terminal nucleotides in the LTR form an inverted repeat of T-G.....C-A; (iii) 6-bp direct repeats of cellular sequences flanking the provirus were present; and (iv) the putative functional signals for initiation or termination of viral RNA synthesis were identified. Comparison of the HTLV-II LTR sequence with that previously published for adult T-cell leukemia virus (ATLV; HTLV-I) shows that the LTRs are distinct. Some small regions are conserved between HTLV-II and ATLV, involving sequences important for transcription and a sequence of 21 nucleotides repeated three times in U3. This 21-bp repeat may be important in regulating viral transcription in lymphoid cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-270683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-305224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-344797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6258797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6261142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6261256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6275274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6275354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6276775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6277502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6280174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6287295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6290401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6294664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6300684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6304725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6308605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6312323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6316141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6316341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6409417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6409418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6409419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6600519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6980467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-6981847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-7031654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-7066985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-729003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-7326747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-822353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6322188-922889
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1079-83
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6322188-Base Sequence,
pubmed-meshheading:6322188-Cloning, Molecular,
pubmed-meshheading:6322188-DNA, Viral,
pubmed-meshheading:6322188-DNA Restriction Enzymes,
pubmed-meshheading:6322188-Deltaretrovirus,
pubmed-meshheading:6322188-Genes, Viral,
pubmed-meshheading:6322188-Humans,
pubmed-meshheading:6322188-Leukemia, Hairy Cell,
pubmed-meshheading:6322188-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:6322188-T-Lymphocytes
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pubmed:year |
1984
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pubmed:articleTitle |
Nucleotide sequence analysis of the long terminal repeat of human T-cell leukemia virus type II.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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