Linked Life Data

6321376

Source:http://linkedlifedata.com/resource/pubmed/id/6321376

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1984-4-26
pubmed:abstractText
Event-related brain potentials, autonomic responses, and response latency under distraction conditions served to investigate the effects of an ACTH 4-9 derivative (ORG 2766) on attention. Male volunteers (45) received either 40 mg ORG 2766 or placebo in a double-blind setting. Two-stimulus trials with acoustic warning signal (S1) and acoustic S2 which had to be interrupted by immediate button press, preceded trials with distraction during the warning interval in 50% of the trials. A final period without distraction served to test for rebound effects. A reduction in early CNV was found in placebo subjects under distraction, while subjects under ORG 2766 showed no reduced early negativity, but increased late negativity under this condition. Peptide subjects differed from controls in evoked potential components, showing enhanced N1 and P3 amplitudes. Activity in the alpha band was elevated. Postexperimental systolic blood pressure was raised by 15 mm Hg under ORG 2766. Results are in agreement with previous findings and suggest ORG 2766 effects on distraction resistance and attention fixation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0020-7454
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-36
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Distractability under the influence of an ACTH 4-9 derivative.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial, Research Support, Non-U.S. Gov't