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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1984-4-24
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pubmed:abstractText |
Adenosine, 2-chloroadenosine and prostaglandin E1 which are known to increase cyclic AMP in neuroblastoma cells potentiated the acetylcholine-induced muscarinic hyperpolarization of the cells without changing the resting membrane potential. The potentiation caused by 2-chloroadenosine was further augmented by Ro 20-1724, a phosphodiesterase inhibitor. A direct intracellular pressure application of cyclic AMP potentiated the muscarinic hyperpolarization without changing the resting membrane potential. Morphine which inhibits adenylate cyclase antagonized 2-chloroadenosine-induced potentiation of the muscarinic hyperpolarization. These results suggest that changes in cyclic AMP level modulate the muscarinic response of neuroblastoma cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
294
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6320977-2-Chloroadenosine,
pubmed-meshheading:6320977-4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,
pubmed-meshheading:6320977-Acetylcholine,
pubmed-meshheading:6320977-Adenosine,
pubmed-meshheading:6320977-Alprostadil,
pubmed-meshheading:6320977-Animals,
pubmed-meshheading:6320977-Cyclic AMP,
pubmed-meshheading:6320977-Dopamine,
pubmed-meshheading:6320977-Iontophoresis,
pubmed-meshheading:6320977-Membrane Potentials,
pubmed-meshheading:6320977-Mice,
pubmed-meshheading:6320977-Morphine,
pubmed-meshheading:6320977-Muscarine,
pubmed-meshheading:6320977-Neuroblastoma,
pubmed-meshheading:6320977-Prostaglandins E
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pubmed:year |
1984
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pubmed:articleTitle |
Cyclic AMP-mediated potentiation of muscarinic hyperpolarization in neuroblastoma cells.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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