Linked Life Data

6320587

Source:http://linkedlifedata.com/resource/pubmed/id/6320587

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-3-12
pubmed:abstractText
Calcium infusion imply a risk for cardiovascular complications. To avoid the risk, we have developed a new method for calcium infusion in man which can keep ionized calcium concentration in whole blood (WB-Ca++) in a steady state at a predetermined level. A solution of calcium chloride (Calcii chlor. Nord.), containing 0.117 mmol Ca++/ml water, is infused intravenously by means of an IMED 922H infusion pump. WB-Ca++ is determined every 5-10 min with a calcium ion-selective electrode, NOVA 2. The infusion rate is continuously adjusted. With the same initial infusion rate, 0.31 mmol Ca++/kg b.w./hour, hypercalcemia that is WB-Ca++ above 1.27 mmol/l was reached within 10 min in healthy volunteers, 8 females with a mean age of 26 years (range 19-36) and 7 males with a mean age of 29 years (range 25-34). The presettled WB-Ca++ level, 1.45 mmol/l, was obtained within 25 min and maintained in a steady state for 155 min at 1.45 +/- 0.01 mmol/l (mean +/- SE) in the female and at 1.46 +/- 0.01 mmol/l in the males. The range of the individual steady state mean WB-Ca++ was 1.42 +/- 0.02 mmol/l. No side-effects of the infusion were noted except for a slight increase in systolic and diastolic blood pressure 60 min after start of the infusion. In conclusion, the calcium clamp technique is safe and suitable for such situations where a presettled easily controlled WB-Ca++ level is required.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0001-6772
pubmed:author
pubmed:issnType
Print
pubmed:volume
119
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
387-92
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
A calcium clamp technique in man.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't