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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1984-3-21
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pubmed:abstractText |
In rats, vitamin D-deficiency increases basal pain threshold and the analgesic effect of morphine (hot plate test). Cholecalciferol (1000 I.U./Kg/day s.c.x 5 days) restores pain sensitivity in vitamin D-deficient rats and brings the analgesic effect of morphine back to normal. On the other hand, tolerance to morphine develops faster in vitamin D-deficient rats, this effect too being prevented by cholecalciferol treatment. These data suggest a role for vitamin D status in pain sensitivity and opiate activity.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
|
pubmed:issn |
0024-3205
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
30
|
pubmed:volume |
34
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
461-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6319945-Animals,
pubmed-meshheading:6319945-Calcium,
pubmed-meshheading:6319945-Cholecalciferol,
pubmed-meshheading:6319945-Drug Tolerance,
pubmed-meshheading:6319945-Morphine,
pubmed-meshheading:6319945-Pain,
pubmed-meshheading:6319945-Rats,
pubmed-meshheading:6319945-Rats, Inbred Strains,
pubmed-meshheading:6319945-Sensory Thresholds,
pubmed-meshheading:6319945-Vitamin D Deficiency
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pubmed:year |
1984
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pubmed:articleTitle |
Pain threshold and morphine activity in vitamin D-deficient rats.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|