Linked Life Data

6319929

Source:http://linkedlifedata.com/resource/pubmed/id/6319929

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1984-3-2
pubmed:abstractText
The demonstration of the immunoreactive proopiomelanocortin (POMC) peptides beta-endorphin (beta-E), beta-lipotropin (beta-LPH), alpha-melanotropin (alpha-MSH), and corticotropin (ACTH) in the human placenta or in tissue cultures of placental origin using radioimmuno-, bio-, or radioreceptor assay suggested that opioid peptide hormones or their precursors are synthesized in the placenta. In order to test this hypothesis, we tried to localize opioid peptides immunohistochemically. On neighbouring sections of the placenta which were incubated with antisera against beta-E, beta-LPH, alpha-MSH, ACTH, BAM-12 P, BAM-22 P, Heptapeptide, alpha-Neoendorphin and Dynorphin 1-17, the immunoperoxidase method was used. The placenta and the pituitary of perfusion-fixed rats were used for controls. The negative immunohistochemical findings in the human and rat placenta do not support the view that beta-E, beta-LPH, alpha-MSH and ACTH are synthesized in the syncytiotrophoblast of this organ. The site of origin of proopiomelanocortin peptides which are present in the maternal and the fetal plasma most likely is the maternal and fetal pituitary.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:volume
33 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
777-80
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Immunohistochemical studies on opioid peptides in the human placenta.
pubmed:publicationType
Journal Article