Linked Life Data

6318905

Source:http://linkedlifedata.com/resource/pubmed/id/6318905

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1984-3-12
pubmed:abstractText
We have followed the increase in miniature end-plate potential (MEPP) frequency that occurs during tetanic stimulation of the motor nerve in low Ca2+ and in Mn2+ saline solutions. During stimulation in either solution the frequency rises over the first minutes to reach an asymptote. In low Ca2+ solutions, hypertonicity increases the rate at which the MEPP frequency rises. Raising the [Mn2+] also increases the rate at which the MEPP frequency rises and elevates the level of the asymptote. The data are interpreted by using a model in which quantal release frequency is proportional to the [( Ca2+])n in the nerve terminal; the model specifically includes the [Ca2+] in the terminal before stimulation. There is evidence that hypertonic solutions elevate the [Ca2+]i. We suggest that the effects of tonicity increases can be accounted for solely by the rise in [Ca2+]i before the beginning of the tetanus. If the number of Ca2+ cooperating in release, n, is 4, then with each stimulus there must be an increase in Ca2+ influx. If the value of n is higher, for example 50, the amount of Ca2+ entering with each stimulus is roughly constant. The data from the Mn2+ experiments also suggest than n may be greater than 4. It is pointed out that for exocytotic transmitter release, many Ca2+ ions may cooperate in the release process, so high values of n are not unreasonable.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
289
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
79-85
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Elevated tonicity increases miniature end-plate potential frequency during tetanic stimulation at frog neuromuscular junction in low calcium and in manganese saline solutions.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't