Linked Life Data

6318566

Source:http://linkedlifedata.com/resource/pubmed/id/6318566

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1984-2-14
pubmed:abstractText
This Editorial Review describes the mechanisms that have been identified for mediating active H+ secretion across the luminal membrane of the proximal tubular cell. These include Na+-H+ exchange, Na+-phosphate cotransport, organic anion-OH- exchange, ATP-driven H+ transport, and redox-driven H+ transport. Of these, Na+-H+ exchange appears to be the most important. Indeed, there is no conclusive evidence against the concept that luminal membrane Na+-H+ exchange is the principal if not the sole mechanism for mediating active H+ secretion in the proximal tubule. The transport properties of the Na+-H+ exchanger, particularly its striking sensitivity to intracellular pH, can explain many aspects of how the rate of active H+ secretion in the proximal tubule is regulated in response to various physiologic stimuli. Certainly, important physiologic roles for other H+ secretory mechanisms, especially those involving primary active H+ secretion, have not been excluded. Nevertheless, there is not yet definitive proof that ATP-driven or redox-driven H+ pumps are located on the luminal membrane itself or that they significantly contribute to transtubular H+ secretion.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
245
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
F647-59
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Mechanisms of active H+ secretion in the proximal tubule.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't