|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1984-2-15
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Previous studies with wild-type simian virus 40 DNA have shown that the sequence 5'-GAGGC-3' directs the binding of A protein (T antigen). The functional origin of replication contains four recognition pentanucleotides each of which is separated by a single base pair and arranged a two pairs of direct repetitions that are inverted relative to each other. Analysis of A protein binding to a series of nonviable mutants progressively deleting these contact sites leads to the following conclusions: (i) stable binding of subunits of A protein to three origin pentanucleotides is not sufficient for the initiation of DNA replication, (ii) the stability of DNA binding depends on interactions between bound protein subunits, and (iii) a single pentanucleotide is sufficient to bind and orient a subunit of A protein.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-205802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-226310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-229233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-4343541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-4343955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-6178514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-6251230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-6253143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-6254000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-6256739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-6270901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-6270902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-6288963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-6292510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-6298451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317897-6298452
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0022-538X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
49
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
9-13
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1984
|
|
pubmed:articleTitle |
Binding of simian virus 40 a protein to DNA with deletions at the origin of replication.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
