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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3-4
|
| pubmed:dateCreated |
1984-2-14
|
| pubmed:abstractText |
Tolerance developed to the cataleptogenic effects of delta 8-tetrahydrocannabinol (delta 8-THC) and 11-hydroxy-delta 8-THC on daily administration (5 mg/kg per day i.v.) of these substances in mice. Reciprocal cross-tolerance was also demonstrated between both cannabinoids. The ED50S (mg/kg i.v.) for delta 8-THC and 11-hydroxy-delta 8-THC were 13.0 (10.2-16.5) and 5.3 (3.4-8.2), respectively, in delta 8-THC-tolerant mice (7 days' treatment) while the corresponding ED50S were 20.8 (17.6-24.5) and 11.7 (8.5-15.7), respectively, in 11-hydroxy-delta 8-THC-tolerant mice. These values were much higher than those in the vehicle-treated mice [delta 8-THC, 4.1 (2.8-5.9); 11-hydroxy-delta 8-THC, 0.98 (0.53-1.81)].
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0014-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
28
|
| pubmed:volume |
94
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
349-51
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:6317407-Animals,
pubmed-meshheading:6317407-Catalepsy,
pubmed-meshheading:6317407-Dose-Response Relationship, Drug,
pubmed-meshheading:6317407-Drug Tolerance,
pubmed-meshheading:6317407-Humans,
pubmed-meshheading:6317407-Male,
pubmed-meshheading:6317407-Mice,
pubmed-meshheading:6317407-Tetrahydrocannabinol
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
Development of tolerance and cross-tolerance to the cataleptogenic effects of delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol in mice.
|
| pubmed:publicationType |
Journal Article
|