Linked Life Data

6317406

Source:http://linkedlifedata.com/resource/pubmed/id/6317406

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1984-2-14
pubmed:abstractText
[3H]Imipramine binds to rat lung membranes. The binding is saturable, of high affinity and sodium-dependent. Drug displacement studies indicate that the binding site in rat lung is similar to that already described in the brain cortex. Tricyclic antidepressants inhibited [3H]imipramine binding in the lung in the low nanomolar range and through a competitive interaction. Serotonin and non-tricyclic serotonin uptake blockers inhibited [3H]imipramine binding in lung in a complex manner. Our results support the view that [3H]imipramine binding and the serotonin recognition site of the transporter are related but not identical.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
345-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Specific high affinity [3H]imipramine binding sites in rat lung are associated with a non-neuronal uptake site for serotonin.
pubmed:publicationType
Journal Article, In Vitro