Linked Life Data

6317186

Source:http://linkedlifedata.com/resource/pubmed/id/6317186

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 1
pubmed:dateCreated
1984-2-14
pubmed:abstractText
We have isolated chicken cDNA and genomic clones for the intermediate filament subunit vimentin and show that the gene for this protein, which exists in a single copy in the haploid chicken genome, is transcribed into two mature mRNA species with approximate lengths of 2.0 and 2.3 kb. We have found cell-specific regulation in the expression of these two mRNAs; whereas both mRNA species are present in muscle cells, fibroblasts, spinal cord and lens, erythroid cells from 10- and 15-day-old chicken embryos express predominantly the lower molecular weight RNA. The difference between these two mRNAs is due to different lengths of their 3' untranslated regions, suggesting that the cell-specific regulation of their expression occurs either by specific termination of transcription or by differential post-transcriptional processing of the 3' untranslated region. Additionally, a remarkable induction (40- to 50-fold) in the abundance of the vimentin mRNA is observed in erythroid cells as chicken development proceeds from 4 to 15 days, which suggests that the level of expression of vimentin during erythroid development is regulated at the transcriptional level.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
411-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Tissue-specific expression of two mRNA species transcribed from a single vimentin gene.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't