Linked Life Data

6317126

Source:http://linkedlifedata.com/resource/pubmed/id/6317126

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-2-24
pubmed:abstractText
[3H]-clonidine binding in vitro and the locomotor response to clonidine in vivo were studied over an eight week period following four weeks of treatment with the monoamine oxidase-inhibiting antidepressant, clorgyline (1 mg kg-1 day-1). Long-term clorgyline administration caused decreases in responsiveness to clonidine and in the number of alpha 2-adrenoceptors; these changes reverted towards pretreatment values very gradually over an eight week period following discontinuation of the drug. This study provides some of the first detailed evidence regarding the slow return of adaptional changes following discontinuation of an antidepressant drug in animals and has implications for understanding some delayed drug interactions associated with MAO-inhibiting antidepressants in man.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10-2
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Correlation of changes in alpha 2-adrenoceptor number and locomotor responses to clonidine following clorgyline discontinuation.
pubmed:publicationType
Journal Article