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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1984-2-14
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pubmed:abstractText |
The effect of ethylenediamine analogues on in vitro binding of [3H]-diazepam to crude cerebral cortical synaptosomal membranes in the rat was studied. Ethylenediamine significantly increased [3H]-diazepam binding to a maximum potentiation of 154% control (EC50 = 1.8 X 10(-4) M) and was the most active compound studied in terms of both potency and the maximum potentiation observed. Potentiation of [3H]-diazepam binding by ethylenediamine analogues is dependent on carbon-chain length, appears to require two terminal amino groups, and is not observed in the rigid analogues studied. Potentiation of [3H]-diazepam binding by ethylenediamine analogues is mediated largely by a change in receptor number and not receptor affinity. Results are discussed in terms of the possible nature of the ethylenediamine binding site.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-1000299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-1086111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-13718948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-19146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-27722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-29760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-30047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-4155790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-4352735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-4725786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-5357245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-5559627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-6101294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-6102883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-6111726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-6282187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-6288605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-6288876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-7062034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-7074290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-7082461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-7139188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-7150875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-715447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-720385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-724104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-7266933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6317124-7378652
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
973-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6317124-Animals,
pubmed-meshheading:6317124-Brain,
pubmed-meshheading:6317124-Diazepam,
pubmed-meshheading:6317124-Drug Synergism,
pubmed-meshheading:6317124-Ethylenediamines,
pubmed-meshheading:6317124-Kinetics,
pubmed-meshheading:6317124-Male,
pubmed-meshheading:6317124-Rats,
pubmed-meshheading:6317124-Rats, Inbred Strains,
pubmed-meshheading:6317124-Receptors, Cell Surface,
pubmed-meshheading:6317124-Receptors, GABA-A,
pubmed-meshheading:6317124-Structure-Activity Relationship
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pubmed:year |
1983
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pubmed:articleTitle |
Structure-activity studies on the potentiation of benzodiazepine receptor binding by ethylenediamine analogues and derivatives.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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