rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1984-1-27
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pubmed:abstractText |
Various proenkephalin-derived peptides such as peptide E and the bovine adrenal medulla peptides BAM-12P and BAM-22P are potent competitors on mu and kappa binding sites in guinea pig brain sections. Moreover, they are all potent agonists in the rabbit vas deferens, a specific kappa opiate receptor bioassay. As described before, dynorphin and some of its fragments are also potent kappa agonists. Our results suggest that not only prodynorphin-derived peptides could act as endogenous kappa ligands but also some proenkephalin-derived peptides such as peptide E.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BAM 12P,
http://linkedlifedata.com/resource/pubmed/chemical/BAM 22P,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Methionine,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, kappa
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pubmed:status |
MEDLINE
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pubmed:issn |
0196-9781
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
445-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6316294-Adrenal Medulla,
pubmed-meshheading:6316294-Animals,
pubmed-meshheading:6316294-Biological Assay,
pubmed-meshheading:6316294-Brain,
pubmed-meshheading:6316294-Enkephalin, Methionine,
pubmed-meshheading:6316294-Enkephalins,
pubmed-meshheading:6316294-Guinea Pigs,
pubmed-meshheading:6316294-Ileum,
pubmed-meshheading:6316294-Kinetics,
pubmed-meshheading:6316294-Male,
pubmed-meshheading:6316294-Mice,
pubmed-meshheading:6316294-Muscle Contraction,
pubmed-meshheading:6316294-Peptides,
pubmed-meshheading:6316294-Protein Precursors,
pubmed-meshheading:6316294-Receptors, Opioid,
pubmed-meshheading:6316294-Receptors, Opioid, kappa,
pubmed-meshheading:6316294-Structure-Activity Relationship,
pubmed-meshheading:6316294-Vas Deferens
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pubmed:articleTitle |
Peptide E and other proenkephalin-derived peptides are potent kappa opiate receptor agonists.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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