|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
1984-1-27
|
|
pubmed:abstractText |
Uptake of serotonin and [3H]imipramine binding were studied in parallel in the platelets of control, depressed and schizophrenic patients. In the depressed patient group, uptake of serotonin was consistently reduced while [3H]imipramine binding was only decreased in a number of these patients. In the schizophrenic group, uptake of serotonin was reduced to 62% of control with no changes in [3H]imipramine binding being observed. These data demonstrate a clear dissociation between uptake of serotonin and [3H]imipramine binding sites in human platelets. The possible functional role of these [3H]imipramine binding sites remains to be determined.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0028-3908
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
22
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1211-4
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6316192-Blood Platelets,
pubmed-meshheading:6316192-Carrier Proteins,
pubmed-meshheading:6316192-Depressive Disorder,
pubmed-meshheading:6316192-Female,
pubmed-meshheading:6316192-Humans,
pubmed-meshheading:6316192-Imipramine,
pubmed-meshheading:6316192-Kinetics,
pubmed-meshheading:6316192-Male,
pubmed-meshheading:6316192-Receptors, Drug,
pubmed-meshheading:6316192-Receptors, Neurotransmitter,
pubmed-meshheading:6316192-Schizophrenia,
pubmed-meshheading:6316192-Serotonin
|
|
pubmed:year |
1983
|
|
pubmed:articleTitle |
Lack of association between [3H]imipramine binding sites and uptake of serotonin in control, depressed and schizophrenic patients.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
