Linked Life Data

6315864

Source:http://linkedlifedata.com/resource/pubmed/id/6315864

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1984-1-7
pubmed:abstractText
When primary infection with murine cytomegalovirus (MCMV) was by the intravenous route, the resulting delayed type hypersensitivity (DTH) to MCMV was reduced compared with subcutaneous or intraperitoneal infection. Intravenous injection of 10(3) or more p.f.u. of MCMV also reduced the DTH response to virus injected at the same time subcutaneously. When spleen cells from mice injected intravenously with MCMV 1 to 3 weeks earlier were transferred to subcutaneously infected mice, the resulting DTH response was suppressed. The cells responsible were T cells, being non-adherent and Thy-1 positive; they were not destroyed by complement plus antibody to either Lyt-1 or Lyt-2. Suppression was not transferred by serum. The suppression was antigen-specific; DTH responses induced by sheep red blood cells and by a thymidine kinase-negative strain of herpes simplex virus type 1 were not significantly suppressed by concurrent intravenous infection with MCMV. Suppression of DTH to MCMV caused by intravenously injected MCMV was reduced in mice given 50 mg/kg cyclophosphamide, but not in those given 200 mg/kg. Deoxyguanosine had no effect on the induction of DTH to MCMV.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1317
pubmed:author
pubmed:issnType
Print
pubmed:volume
64 (Pt 11)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2433-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Antigen-specific suppression of delayed type hypersensitivity to murine cytomegalovirus in MCMV-infected mice.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't