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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1984-1-27
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pubmed:abstractText |
We have shown that erythropoietin (epo), the primary regulator of erythrocyte formation, diminished the binding to peritoneal exudate macrophages (PEM) of the principal macrophage growth regulator, colony-stimulating factor (CSF-1). The effect of epo on 125I-CSF-1 binding was dose-dependent; at a concentration of 1-2 U of epo/ml (10(-10) M), CSF-1 binding was almost completely suppressed. Erythropoietin did not compete with CSF-1 for occupancy of the latter's receptors. The effect of epo on CSF-1 binding occurred at 37 degrees C but not at 2 degrees C, and during the continuous exposure of PEM to epo at 37 degrees C we found that CSF-1 binding reached a nadir at 1 h and recovered to pre-exposure levels in 7 h. Our novel results are consistent with the notion that specific receptors for epo exist on the cell surface of PEM and that binding of epo sets in motion a series of cellular events resulting in the internalization of CSF-1 receptors. Thus epo causes down regulation of CSF-1 receptors on PEM. We have previously shown that epo causes suppression of CSF-induced granulocyte-macrophage colony formation by mouse bone marrow cells. The results we present here provide a possible mechanism for these results.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-1089721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-172374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-18467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-301140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-302986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-306388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-307187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-307249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-312116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-435647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-4359334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-4434455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-6254158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-6300136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-6300138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-6300241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-6306017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-6601155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-6965942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-6968317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-6974750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-6981518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-6984345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-7001632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315747-80283
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9525
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1945-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6315747-Animals,
pubmed-meshheading:6315747-Biological Assay,
pubmed-meshheading:6315747-Colony-Stimulating Factors,
pubmed-meshheading:6315747-Erythropoietin,
pubmed-meshheading:6315747-Kinetics,
pubmed-meshheading:6315747-Macrophages,
pubmed-meshheading:6315747-Male,
pubmed-meshheading:6315747-Mice,
pubmed-meshheading:6315747-Mice, Inbred C3H,
pubmed-meshheading:6315747-Receptors, Cell Surface,
pubmed-meshheading:6315747-Receptors, Colony-Stimulating Factor
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pubmed:year |
1983
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pubmed:articleTitle |
Erythropoietin causes down regulation of colony-stimulating factor (CSF-1) receptors on peritoneal exudate macrophages of the mouse.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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