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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1984-1-7
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pubmed:abstractText |
The B (nondiabetogenic) and D (diabetogenic) variants of encephalomyocarditis (EMC) virus were studied to further define the role of the interferon (IFN) system in murine virus-induced diabetes mellitus. The relationship between the initial multiplicity of infection with EMC-B and the IFN yield showed that cells infected with one IFN-inducing particle produce a maximum amount of IFN, whereas IFN production is suppressed in cells infected with two or more particles. The IFN yield induced by EMC-D was less than 5% of that induced by EMC-B, allowing the designation of the B and D variants as Ifp+ and Ifp-, respectively. The Ifp+ property of the virion was shown to be responsible for the greater sensitivity of EMC-B to exogenous IFN as a result of primed local IFN induction. The data indicate that different Ifp phenotypes occur in nature and are associated with the development of diabetes in mice.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315581-13590226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315581-165620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315581-176792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315581-200705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315581-4300932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315581-4327587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315581-4362002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315581-4985819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315581-6180093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315581-6183376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315581-6252275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6315581-6337224
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
605-11
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:6315581-Animals,
pubmed-meshheading:6315581-Cells, Cultured,
pubmed-meshheading:6315581-Diabetes Mellitus, Experimental,
pubmed-meshheading:6315581-Embryo, Mammalian,
pubmed-meshheading:6315581-Encephalomyocarditis virus,
pubmed-meshheading:6315581-Genetic Variation,
pubmed-meshheading:6315581-Interferon Type I,
pubmed-meshheading:6315581-Kinetics,
pubmed-meshheading:6315581-L Cells (Cell Line),
pubmed-meshheading:6315581-Mice,
pubmed-meshheading:6315581-Poly I-C,
pubmed-meshheading:6315581-Viral Plaque Assay
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pubmed:year |
1983
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pubmed:articleTitle |
Relationship of interferon-inducing particle phenotype to encephalomyocarditis virus-induced diabetes mellitus.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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