Linked Life Data

6315151

Source:http://linkedlifedata.com/resource/pubmed/id/6315151

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-1-7
pubmed:abstractText
Subpial injection of aqueous solutions of iron salts into rat isocortex induces recurrent epileptiform discharges with focal brain edema, cavitary necrosis and gliosis. Since aqueous iron or heme compounds cause peroxidation of lipids, we studied the sequence of changes in the formation of free radicals, and superoxide radicals, in rat isocortex injected with 5 microliter of 100 mM FeCl3. Electron spin resonance measurements of whole rat brain showed a transient increase in heme-bound Fe3+. Superoxide radicals were increased in a cylinder of tissue obtained at the injection site 5 min and 15 min after completion of the injection. This study shows that iron salts injected into rat isocortex cause transient formation of free radicals. We suggest that decompartmentalization of iron compounds may be of importance in trauma-related brain injury responses.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
277
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
393-6
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Formation of superoxide radicals after FeCl3 injection into rat isocortex.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't