Linked Life Data

6315030

Source:http://linkedlifedata.com/resource/pubmed/id/6315030

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-1-27
pubmed:abstractText
A new antiarrhythmic drug of phenothiazine series diethylamine ethmozine analogue inhibited the rabbit's platelet aggregation induced by ADP, serotonin and thrombin. The degree of inhibition depended on the drug concentration and time of its incubation with platelets as well as on the inducer concentration. The transition from ADP-induced (5 microM) aggregation to reversible one was observed under the influence of relatively small doses of the drug. A gradual restoration of the platelet aggregating capacity occurred after washing platelets off the drug. The nonadditive character of the studied agent effects and that of theophylline on the platelets makes it possible to suppose that cAMP participates in the mechanism of the drug action on the platelets. The described antiaggregating effect of the drug on the platelets should be taken into account when it is used as an antiarrhythmic agent.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0201-7369
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
64-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
[Antiaggregating action on thrombocytes of a new anti-arrhythmia agent of the phenothiazine series--diethylamine ethmozine analog].
pubmed:publicationType
Journal Article, In Vitro, English Abstract