Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1983-12-17
pubmed:abstractText
Different states of eukaryotic gene expression are often correlated with different levels of methylation of DNA sequences containing structural genes and their flanking regions. To assess the potential role of DNA methylation in the expression of immunoglobulin genes, which require complex rearrangements prior to expression, methylation patterns were examined in cell lines representing different stages of lymphocyte maturation. Methylation of the second cytosine in the sequence 5' C-C-G-G 3' was determined by using Hpa II/Msp I endonuclease digestion. Four CH genes (C mu, C delta, C gamma 2b, and C alpha), C kappa, V kappa, C lambda, and V lambda genes were analyzed. The results lead to the following conclusions: (i) transcribed immunoglobulin genes are undermethylated; (ii) the C gene allelic to an expressed C gene is always also undermethylated; and (iii) all immunoglobulin loci tend to become increasingly undermethylated as B cells mature.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-109919, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-111144, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-112480, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-115000, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-117548, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-117549, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-1195397, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-161906, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-303524, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-369952, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-408080, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-4129807, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-508729, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6254144, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6255422, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6255429, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6260146, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6262318, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6264313, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6264446, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6267606, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6287471, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6308642, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6769113, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6769117, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6774414, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6780916, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6783958, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6787586, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6787604, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6791832, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6793877, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6795624, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6801528, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6801628, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6801653, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6804095, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6812053, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-6968091, http://linkedlifedata.com/resource/pubmed/commentcorrection/6314334-7070505
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6642-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.