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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1983-12-20
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pubmed:abstractText |
Single channel currents induced by acetylcholine were recorded from nerve growth factor-differentiated clonal rat pheochromocytoma (PC12) cells by using the patch-clamp technique. Inward current amplitudes were heterogeneous and could be related to three classes of unitary current. The three current-voltage relations were linear for patch membrane potentials ranging from -50 mV to -120 mV. At 22 degrees C, conductances of 22 pS, 31 pS and 39 pS were obtained. The extrapolated reversal potential for the channels was 0 mV and the mean open time approximately 10-20 ms. These results may indicate that PC12 cells possess three types of acetylcholine receptor channels.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
193-7
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:6314212-Acetylcholine,
pubmed-meshheading:6314212-Adrenergic Fibers,
pubmed-meshheading:6314212-Animals,
pubmed-meshheading:6314212-Clone Cells,
pubmed-meshheading:6314212-Ganglia, Sympathetic,
pubmed-meshheading:6314212-Ion Channels,
pubmed-meshheading:6314212-Membrane Potentials,
pubmed-meshheading:6314212-Models, Neurological,
pubmed-meshheading:6314212-Neurons,
pubmed-meshheading:6314212-Pheochromocytoma,
pubmed-meshheading:6314212-Rats,
pubmed-meshheading:6314212-Synaptic Transmission
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pubmed:year |
1983
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pubmed:articleTitle |
Three types of acetylcholine-induced single channel currents in clonal rat pheochromocytoma cells.
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pubmed:publicationType |
Journal Article
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