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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1983-12-20
|
| pubmed:abstractText |
The flora in the throat and the stools of 10 patients receiving chemotherapy for malignant diseases in a laminar air-flow room was studied during the prophylactic administration of ceftazidime. Ten percent of aerobic gram-negative bacilli, 41% of aerobic gram-positive organisms, 59% of anaerobes, and 70% of fungi persisted in stool specimens during ceftazidime administration. This drug had a less pronounced effect on the throat flora; 66% of organisms persisted during antibiotic administration. The throat and fecal flora of another eight patients were studied during the prophylactic administration of ceftriaxone. This antibiotic had a profound effect on the fecal flora; none of the gram-negative bacilli, only 24% of aerobic gram-positive organisms, and only 10% of anaerobes persisted during ceftriaxone administration. Like ceftazidime, ceftriaxone had a less marked effect on the throat flora; 59% of organisms persisted during antibiotic administration. The results show that new, expanded-spectrum cephalosporins can have a major suppressive effect on patients' endogenous microbial flora.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
148
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
892-7
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6313821-Adult,
pubmed-meshheading:6313821-Aged,
pubmed-meshheading:6313821-Bacterial Infections,
pubmed-meshheading:6313821-Bacteroides,
pubmed-meshheading:6313821-Candidiasis,
pubmed-meshheading:6313821-Cefotaxime,
pubmed-meshheading:6313821-Ceftazidime,
pubmed-meshheading:6313821-Ceftriaxone,
pubmed-meshheading:6313821-Cephalosporins,
pubmed-meshheading:6313821-Cross Infection,
pubmed-meshheading:6313821-Drug Resistance, Microbial,
pubmed-meshheading:6313821-Enterobacteriaceae,
pubmed-meshheading:6313821-Feces,
pubmed-meshheading:6313821-Female,
pubmed-meshheading:6313821-Humans,
pubmed-meshheading:6313821-Male,
pubmed-meshheading:6313821-Middle Aged,
pubmed-meshheading:6313821-Neoplasms,
pubmed-meshheading:6313821-Pharynx,
pubmed-meshheading:6313821-Staphylococcus,
pubmed-meshheading:6313821-Streptococcus
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
Effect of broad-spectrum cephalosporins on the microbial flora of recipients.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|