Linked Life Data

631377

Source:http://linkedlifedata.com/resource/pubmed/id/631377

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1978-5-24
pubmed:abstractText
The numbers and nucleolar activity of lymphocytes were followed in the control and SRBC-stimulated popliteal lymph nodes following administration of known immunosuppressive agents of different classes which were given in doses effective in the Jerne test and graft-versus-host reaction. Immunosuppressive agents had a non-selective effect on different lymphocyte populations (characterized by the activity of nucleolar RNA synthesis) in the control, antigen-untreated lymph nodes, but had a marked inhibitory effect on lymphocytes with compact nucleoli in the antigen-stimulated lymph nodes. This decrease is in good correlation with suppression of the Jerne haemolytic plaques and GVHR. The nucleolar test as a simple technique appears to be adequate for a rapid screening of immunosuppressive activity of the chemical and biological agents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0015-5500
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-50
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
"Nucleolar test" as a system for screening and analysis of immunosuppressive activity of chemical and biological agents.
pubmed:publicationType
Journal Article