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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1983-12-21
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pubmed:abstractText |
Human peripheral blood monocytes have high affinity binding sites for 1,25-(OH)2D3 (Kd 0.14 nM, sedimentation coefficient 3.7S). Resting human peripheral blood T lymphocytes, however, do not have a demonstrable 1,25-(OH)2D3 receptor. After activation with phytohemagglutinin the T cells exhibit the receptor within 24 h, and this expression is blocked by cycloheximide. The receptor in activated T lymphocytes has a sedimentation coefficient of 3.7S and a high affinity (Kd 0.10 nM) for the ligand.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-972X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1308-10
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6313738-Calcitriol,
pubmed-meshheading:6313738-Centrifugation, Density Gradient,
pubmed-meshheading:6313738-Humans,
pubmed-meshheading:6313738-Kinetics,
pubmed-meshheading:6313738-Lymphocyte Activation,
pubmed-meshheading:6313738-Monocytes,
pubmed-meshheading:6313738-Phytohemagglutinins,
pubmed-meshheading:6313738-Receptors, Calcitriol,
pubmed-meshheading:6313738-Receptors, Steroid,
pubmed-meshheading:6313738-T-Lymphocytes
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pubmed:year |
1983
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pubmed:articleTitle |
Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation.
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pubmed:publicationType |
Journal Article
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