| pubmed-article:6312300 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6312300 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:6312300 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:6312300 | lifeskim:mentions | umls-concept:C0018555 | lld:lifeskim |
| pubmed-article:6312300 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:6312300 | lifeskim:mentions | umls-concept:C0054412 | lld:lifeskim |
| pubmed-article:6312300 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:6312300 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6312300 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6312300 | pubmed:dateCreated | 1983-11-23 | lld:pubmed |
| pubmed-article:6312300 | pubmed:abstractText | Inducibility of 6-thioguanine-resistant (6TGr) mutants and single-strand scission of DNA by cadmium chloride (CdCl2) was investigated in cultured Chinese hamster V79 cells. Frequency of 6TGr mutants increased concentration dependently by 24-h treatment with CdCl2 up to 3 X 10(-6) M but decreased beyond 3 X 10(-6) M. Mutagenic potency of cadmium in the absence of S9 was about half that of benzo[a]pyrene in the presence of S9 at equitoxic concentrations. Treatment of the cultured cells with cadmium after benzo[a]pyrene treatment was not synergistic but additive to the mutagenicity of benzo[a]pyrene. Single-strand scission of DNA by alkaline elution techniques was observed in the cells treated with CdCl2 for 2 h in a concentration-dependent manner. The single-strand scission by cadmium was detected only in combination with proteinase K digestion of the cell lysates, indicating formation of DNA--protein cross-linking by the metal. These biological and biochemical findings indicate that cadmium is mutagenic in mammalian cells, and its mutagenic effect seems to be accompanied by single-strand scission of DNA. | lld:pubmed |
| pubmed-article:6312300 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6312300 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6312300 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6312300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6312300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6312300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6312300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6312300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6312300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6312300 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6312300 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6312300 | pubmed:issn | 0027-5107 | lld:pubmed |
| pubmed-article:6312300 | pubmed:author | pubmed-author:OhsawaMM | lld:pubmed |
| pubmed-article:6312300 | pubmed:author | pubmed-author:OchiTT | lld:pubmed |
| pubmed-article:6312300 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6312300 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:6312300 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6312300 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6312300 | pubmed:pagination | 69-78 | lld:pubmed |
| pubmed-article:6312300 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6312300 | pubmed:meshHeading | pubmed-meshheading:6312300-... | lld:pubmed |
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| pubmed-article:6312300 | pubmed:meshHeading | pubmed-meshheading:6312300-... | lld:pubmed |
| pubmed-article:6312300 | pubmed:meshHeading | pubmed-meshheading:6312300-... | lld:pubmed |
| pubmed-article:6312300 | pubmed:meshHeading | pubmed-meshheading:6312300-... | lld:pubmed |
| pubmed-article:6312300 | pubmed:meshHeading | pubmed-meshheading:6312300-... | lld:pubmed |
| pubmed-article:6312300 | pubmed:meshHeading | pubmed-meshheading:6312300-... | lld:pubmed |
| pubmed-article:6312300 | pubmed:meshHeading | pubmed-meshheading:6312300-... | lld:pubmed |
| pubmed-article:6312300 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6312300 | pubmed:articleTitle | Induction of 6-thioguanine-resistant mutants and single-strand scission of DNA by cadmium chloride in cultured Chinese hamster cells. | lld:pubmed |
| pubmed-article:6312300 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6312300 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6312300 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6312300 | lld:pubmed |
