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pubmed-article:6312248pubmed:abstractTextThe specific activities of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase, EC3.1.4.37) in erythrocyte membranes from five patients with active multiple sclerosis (MS) and five normals were compared. The CNPase assay used 2',3'-cyclic NADP as the substrate in an enzyme coupled reaction to produce fluorometrically detectable NADPH. The specific activity of CNPase in the MS and normal groups were 19.2 +/- 2.3 and 28.7 +/- 1.8 mumol/h/mg protein, respectively. The difference was significant with p less than 0.006, based on a one-tailed t-test.lld:pubmed
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pubmed-article:6312248pubmed:articleTitleErythrocyte membrane 2', 3'-cyclic nucleotide 3'-phosphodiesterase activity in multiple sclerosis.lld:pubmed
pubmed-article:6312248pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:6312248pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed