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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1983-11-23
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pubmed:abstractText |
Hepatic alpha-1, alpha-2 and beta-2 adrenoceptors were characterized during development of the rat through Scatchard analysis of [3H]prazosin, [3H]rauwolscine and [125I]pindolol binding to liver membrane preparations. Major changes in adrenoceptor numbers occur shortly before birth at weaning. The fetal rat liver is characterized by a large number of alpha-2 adrenoceptors, which falls 10-fold by birth. The number of hepatic beta-2 adrenoceptors decreases gradually during development, and is lower at all times than the number of alpha-1 and alpha-2 adrenoceptors. The developmental profile of the hepatic alpha-1 adrenoceptor is biphasic: there is a 2 to 3-fold fall in alpha-1 adrenoceptor number at birth and a 3- to 5-fold rise at weaning. While absolute numbers of alpha-1 and beta-2 adrenoceptors do not correlate precisely with reported actions of epinephrine and norepinephrine on hepatic metabolism during ontogeny, the increasing ratio of alpha-1/beta-2 hepatic adrenoceptors may contribute to the conversion from predominantly beta effects of catecholamines reported in fetal and suckling rat liver to the predominantly alpha-1 effects that are well documented in the adult male rat.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Pindolol,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/Secologanin Tryptamine Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Tritium
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-3565
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
227
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
181-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6312016-Animals,
pubmed-meshheading:6312016-Binding Sites,
pubmed-meshheading:6312016-Female,
pubmed-meshheading:6312016-Liver,
pubmed-meshheading:6312016-Male,
pubmed-meshheading:6312016-Pindolol,
pubmed-meshheading:6312016-Prazosin,
pubmed-meshheading:6312016-Rats,
pubmed-meshheading:6312016-Rats, Inbred Strains,
pubmed-meshheading:6312016-Receptors, Adrenergic,
pubmed-meshheading:6312016-Receptors, Adrenergic, alpha,
pubmed-meshheading:6312016-Receptors, Adrenergic, beta,
pubmed-meshheading:6312016-Secologanin Tryptamine Alkaloids,
pubmed-meshheading:6312016-Tritium
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pubmed:year |
1983
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pubmed:articleTitle |
Ontogeny of rat hepatic adrenoceptors.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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