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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
1983-11-23
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pubmed:abstractText |
Plasma norepinephrine concentrations in a group of malnourished patients with anorexia nervosa were significantly (P less than 0.002) lower than those in an age- and sex-matched group of normal subjects. Platelet total alpha-adrenoceptor densities of these patients significantly (P less than 0.002) exceeded those of the controls. The increased total alpha-adrenoceptor density was due to an increase in the alpha 2-adrenoceptor receptor subtype, which mediates epinephrine-induced platelet aggregation. Accordingly, the aggregation response of the patients' platelets was significantly (P less than 0.002) enhanced after epinephrine challenge. We suggest that the starvation-induced fall in plasma norepinephrine levels is associated with the up-regulation of platelet alpha-adrenoceptors. This, in turn, accounts for exaggerated epinephrine-induced platelet aggregation in anorexic patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-972X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
911-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6311864-Adolescent,
pubmed-meshheading:6311864-Adult,
pubmed-meshheading:6311864-Anorexia Nervosa,
pubmed-meshheading:6311864-Blood Platelets,
pubmed-meshheading:6311864-Dihydroergotoxine,
pubmed-meshheading:6311864-Epinephrine,
pubmed-meshheading:6311864-Fatty Acids, Nonesterified,
pubmed-meshheading:6311864-Female,
pubmed-meshheading:6311864-Humans,
pubmed-meshheading:6311864-Norepinephrine,
pubmed-meshheading:6311864-Platelet Aggregation,
pubmed-meshheading:6311864-Receptors, Adrenergic, alpha,
pubmed-meshheading:6311864-Yohimbine
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pubmed:year |
1983
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pubmed:articleTitle |
Platelet hyperaggregability and increased alpha-adrenoceptor density in anorexia nervosa.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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