Linked Life Data

6311366

Source:http://linkedlifedata.com/resource/pubmed/id/6311366

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
1983-11-23
pubmed:abstractText
We have studied inhibitory effects of ellipticine derivatives on the topoisomerisation reactions by Rat liver enzymes. We used the reactions of relaxation of supercoiled DNA, catalysed by topoisomerase I without ATP and by topoisomerase II with ATP, and also the reaction of decatenation of DNA networks by topoisomerase II. When studying intercalating agents--as elliptieine derivatives are--a problem arose. To distinguish relaxed DNA from native DNA we run our samples in electrophoretic gels containing an intercalating agent: chloroquine. Topoisomerase II, which was inhibited at concentrations about 10(-6) M, was more sensitive than topoisomerase I.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0249-6313
pubmed:author
pubmed:issnType
Print
pubmed:volume
296
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
899-904
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
[Inhibition by ellipticine derivatives of the reactions catalysed by the topoisomerases: preferential inhibition of topoisomerase II].
pubmed:publicationType
Journal Article, In Vitro, English Abstract