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rdf:type |
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lifeskim:mentions |
umls-concept:C0001483,
umls-concept:C0007634,
umls-concept:C0012655,
umls-concept:C0017262,
umls-concept:C0018557,
umls-concept:C0020205,
umls-concept:C0024348,
umls-concept:C0033414,
umls-concept:C0038975,
umls-concept:C0205431,
umls-concept:C0312740,
umls-concept:C1510411
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pubmed:issue |
19
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pubmed:dateCreated |
1983-10-28
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pubmed:abstractText |
Weakly oncogenic adenovirus 2 (Ad2)-transformed LSH hamster cells are sensitive to lysis by spontaneously cytolytic lymphoid cells and activated macrophages, whereas highly oncogenic simian virus 40 (SV40)-transformed LSH cells are relatively resistant to these nonspecific effector cells. Somatic cell hybrids formed between Ad2- and SV40-transformed hamster cells, which expressed Ad2 tumor (T) antigens, exhibited an increased cytolytic susceptibility compared to Ad2 T antigen-negative cell hybrids or nonhybrid SV40-transformed cells. No correlation was found between the expression of SV40 T antigen in hybrid cells and cytolytic susceptibility. The results suggest the existence of a novel function for early Ad2 genome-encoded polypeptides (T antigens) expressed in transformed hamster cells--the induction of susceptibility to destruction mediated by immunologically nonspecific effector cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-1234049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-13922417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-14206435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-314331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-315273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-427789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-4558860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-479761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-4861310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-5087653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-5549896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-568181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-6256760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-6273913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-6277479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-6298123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-6303562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-6933049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-6966073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6310610-7025208
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5995-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6310610-Adenoviruses, Human,
pubmed-meshheading:6310610-Animals,
pubmed-meshheading:6310610-Antigens, Viral,
pubmed-meshheading:6310610-Cell Line,
pubmed-meshheading:6310610-Cell Transformation, Neoplastic,
pubmed-meshheading:6310610-Cricetinae,
pubmed-meshheading:6310610-Cytotoxicity, Immunologic,
pubmed-meshheading:6310610-Disease Susceptibility,
pubmed-meshheading:6310610-Embryo, Mammalian,
pubmed-meshheading:6310610-Genes, Viral,
pubmed-meshheading:6310610-Macrophages,
pubmed-meshheading:6310610-Mesocricetus,
pubmed-meshheading:6310610-Simian virus 40
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pubmed:year |
1983
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pubmed:articleTitle |
Adenovirus 2 early gene expression promotes susceptibility to effector cell lysis of hybrids formed between hamster cells transformed by adenovirus 2 and simian virus 40.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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