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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1983-9-9
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pubmed:abstractText |
A cDNA corresponding to the human gene for hypoxanthine phosphoribosyltransferase (HPRT; IMP:pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) has been ligated into murine retroviral vectors such that it is under the transcriptional control of viral long terminal repeats. Transfection of HPRT- cells followed by superinfection with various helper viruses has led to the rescue of chimeric virus capable of transmitting the HPRT+ phenotype to HPRT- rodent or human cells. These genetically transformed cells contain authentic human HPRT at levels similar to normal HPRT+ cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-1170183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-13776896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-14200349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-181592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-210957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-215915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-228482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-369702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-4099080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-4120821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-4368895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-4705382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-569362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6169994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6173134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6180306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6251455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6253083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6253670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6254003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6255210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6256082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6270359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6276009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6278709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6292525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6300847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6445561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-6933701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-7292260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308645-856944
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4709-13
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6308645-Animals,
pubmed-meshheading:6308645-Cell Line,
pubmed-meshheading:6308645-Cloning, Molecular,
pubmed-meshheading:6308645-DNA,
pubmed-meshheading:6308645-Genes,
pubmed-meshheading:6308645-Genes, Viral,
pubmed-meshheading:6308645-Helper Viruses,
pubmed-meshheading:6308645-Humans,
pubmed-meshheading:6308645-Hypoxanthine Phosphoribosyltransferase,
pubmed-meshheading:6308645-Mice,
pubmed-meshheading:6308645-Mice, Inbred BALB C,
pubmed-meshheading:6308645-Rats,
pubmed-meshheading:6308645-Rats, Inbred F344,
pubmed-meshheading:6308645-Retroviridae,
pubmed-meshheading:6308645-Simian virus 40,
pubmed-meshheading:6308645-Transfection
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pubmed:year |
1983
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pubmed:articleTitle |
A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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