Linked Life Data

6308495

Source:http://linkedlifedata.com/resource/pubmed/id/6308495

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-9-20
pubmed:abstractText
Norepinephrine (NE) may have a major role in modulating the responsiveness of Purkinje cells to the actions of other neurotransmitters in the cerebellum. Specifically, the catecholamine has been shown to enhance inhibitory responses of Purkinje cells to microiontophoretically applied gamma-aminobutyric acid (GABA). This noradrenergic facilitation of GABA has been shown recently to be mediated by beta-adrenergic receptors. The aim of this study was to characterize further the subtype of the beta-receptor involved. The results indicate that practolol, a selective beta-1 blocker, antagonized the NE-induced augmentation of Purkinje cell inhibitory responses to GABA. Zinterol, a selective beta-2 agonist, did not mimic the potentiating effect of NE. Furthermore, the noradrenergic facilitation of GABA-induced inhibition remained unaltered in cerebella subjected to neonatal X-irradiation. This procedure resulted in a decrease in the total cerebellar beta-receptor population yet left unchanged both the number of beta-1 receptors per cerebellum and the radio-resistant Purkinje cells. Together, the data presented here support the hypothesis that the noradrenergic facilitation of GABA-induced inhibition of Purkinje cells is mediated by the activation of cerebellar beta-1 adrenergic receptors located on the Purkinje cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0028-3908
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
629-39
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Beta-1 adrenergic receptors mediate noradrenergic facilitation of Purkinje cell responses to gamma-aminobutyric acid in cerebellum of rat.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't