Linked Life Data

6308035

Source:http://linkedlifedata.com/resource/pubmed/id/6308035

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-9-20
pubmed:abstractText
The activities of flavin-linked, mitochondrial glycerol phosphate dehydrogenase in islet cell adenomas from two infants were 8 and 16 times higher than those in their uninvolved pancreases. The enzyme in the insulinomas, but not that in the nearby pancreases, was inhibited by diazoxide, which is a known inhibitor of insulin secretion in vitro and in vivo. These results provide preliminary evidence that the enzyme may be used as an adjunct to histology for identifying human insulin-secreting tissues. Its sensitivity to diazoxide adds specificity to the test. Taken together with previous work with animal pancreatic islets, the results of the present study suggest that the glycerol phosphate shuttle plays an important role in stimulus-secretion coupling in the pancreatic beta-cell.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
662-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Increased mitochondrial glycerol phosphate dehydrogenase activity in insulinomas of two hypoglycemic infants.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Case Reports, Research Support, Non-U.S. Gov't