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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1983-9-9
|
| pubmed:abstractText |
We have defined a new type of delta-thalassemia in which beta-globin chain synthesis is incompletely suppressed. Homozygotes have unusually low HbA2 levels, and double heterozygosity for this delta-thalassemia gene and beta-thalassemia normalizes the HbA2 level. The delta-thalassemia occurs on a chromosome that is identifiable using polymorphic restriction endonuclease sites. We call this condition delta +-thalassemia, to distinguish it from the previously described delta 0-thalassemia syndromes in which no delta-globin chain synthesis occurs.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
62
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
341-5
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6307432-Chromosome Mapping,
pubmed-meshheading:6307432-DNA Restriction Enzymes,
pubmed-meshheading:6307432-Hemoglobin A2,
pubmed-meshheading:6307432-Hemoglobins, Abnormal,
pubmed-meshheading:6307432-Heterozygote,
pubmed-meshheading:6307432-Homozygote,
pubmed-meshheading:6307432-Humans,
pubmed-meshheading:6307432-Italy,
pubmed-meshheading:6307432-Male,
pubmed-meshheading:6307432-Pedigree,
pubmed-meshheading:6307432-Thalassemia
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
Delta +-thalassemia in Sardinia.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|