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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1983-8-11
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pubmed:abstractText |
The phosphotransferase system of human central-nervous-system myelin was investigated. Evidence obtained indicated the presence of at least two different phosphotransferase systems (cyclic nucleotide-dependent and -independent) in myelin, which were found to be firmly associated with the membrane. The cyclic AMP-dependent kinase of myelin and white-matter cytosol preferentially phosphorylated certain histone fractions and displayed only modest activity with basic protein as substrate. On the other hand, the cyclic nucleotide-independent system showed specificity toward basic protein. Its activity was not only dependent on Mg2+ but it was greatly enhanced by this bivalent cation. Whereas the cyclic nucleotide-dependent kinase could be extracted with buffers containing Triton X-100, the bivalent cation-regulated kinase resisted solubilization from myelin under these conditions.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-1122028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-163295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-17614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-182038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-188988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-209141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-234451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-23846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-4117553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-4133355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-4137880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-430044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-4306466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-4306869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-4311933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-4322439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-4359021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-4375762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-4623901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-4833512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-5806584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-6153368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-6157564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-6160873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-6162425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-7082288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6307265-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
209
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
789-95
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:6307265-Brain,
pubmed-meshheading:6307265-Carrier Proteins,
pubmed-meshheading:6307265-Cations, Divalent,
pubmed-meshheading:6307265-Cyclic AMP,
pubmed-meshheading:6307265-Humans,
pubmed-meshheading:6307265-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:6307265-Kinetics,
pubmed-meshheading:6307265-Lipids,
pubmed-meshheading:6307265-Myelin Sheath,
pubmed-meshheading:6307265-Octoxynol,
pubmed-meshheading:6307265-Osmolar Concentration,
pubmed-meshheading:6307265-Phosphorylation,
pubmed-meshheading:6307265-Polyethylene Glycols,
pubmed-meshheading:6307265-Protein Kinases,
pubmed-meshheading:6307265-Solubility,
pubmed-meshheading:6307265-Substrate Specificity
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pubmed:year |
1983
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pubmed:articleTitle |
Partial characterization of the phosphotransferase system of human central-nervous-system myelin.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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