Linked Life Data

6305835

Source:http://linkedlifedata.com/resource/pubmed/id/6305835

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-8-26
pubmed:abstractText
Pulmonary bactericidal mechanisms are reduced during viral pneumonia. It has been proposed that secondary bacterial pneumonia occurs because the host's ability to mount an inflammatory response is suppressed. These studies examine the pathobiology of parainfluenza 1 virus and viral-associated staphylococcal pneumonia in a murine model. The sequence of leukocyte and fluid protein changes were studied in the lung and blood. An influx of polymorphonuclear leukocytes into the lungs occurred early in the viral infection, and coincided with lung macrophages aggregation. Maximal increases in pulmonary leukocytes occurred during the period associated with maximum suppression of lung bactericidal mechanisms (days 7-9). During this period, the host was capable of mounting an additional inflammatory response to staphyloccal challenges. Finally, viral pneumonia resulted in a prolonged elevation in the numbers of pulmonary macrophages, lymphocytes, and granulocytes. Thus, changes in lung biology persisted well after resolution of the initiating infections.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0360-3997
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-104
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Pulmonary inflammatory responses during viral pneumonia and secondary bacterial infection.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.