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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
1983-8-11
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pubmed:abstractText |
Several biological phenotypes of growth factor-dependent cell lines have been described in recent years, including those with T lymphocyte, neutrophil granulocyte, basophil/mast cell, B lymphocyte, and multipotential stem cell properties. The growth factors for each cell lineage are a subject of intense study. Continuous mouse bone marrow cultures infected with RNA type C viruses (retroviruses) produce nonadherent hematopoietic cells over a longer duration than control cultures. Marrow cultures derived from strains with spontaneously induced ecotropic endogenous retrovirus demonstrate a greater longevity than those from strains with no replicating virus. Cultures infected with murine leukemia virus also generate a greater number, compared with controls, of cloned permanent suspension cell lines dependent for growth on a 41,000-dalton glycoprotein (interleukin 3 [IL 3]). Some are multipotential with capacity for differentiation to erythroid, neutrophil, eosinophil, and basophil/mast cell types. Other cloned IL 3-dependent cell lines are committed to a single pathway. Studies with Friend spleen focus-forming virus indicate that the first effect in the marrow culture is mediated through a subset of adherent hematopoietic stem cells. Bone marrow culture-derived IL 3-dependent cell lines provide a model with which to study the role of viral genes in the control of differentiation and self-renewal capacity of hematopoietic stem cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-9446
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2762-71
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:6305732-Animals,
pubmed-meshheading:6305732-B-Lymphocytes,
pubmed-meshheading:6305732-Cell Line,
pubmed-meshheading:6305732-Cell Transformation, Neoplastic,
pubmed-meshheading:6305732-Colony-Forming Units Assay,
pubmed-meshheading:6305732-Hematopoietic Stem Cells,
pubmed-meshheading:6305732-Interleukin-3,
pubmed-meshheading:6305732-Leukemia, Experimental,
pubmed-meshheading:6305732-Leukemia Virus, Murine,
pubmed-meshheading:6305732-Lymphokines,
pubmed-meshheading:6305732-Mice,
pubmed-meshheading:6305732-Mice, Inbred Strains,
pubmed-meshheading:6305732-Muramidase,
pubmed-meshheading:6305732-Polycythemia,
pubmed-meshheading:6305732-Species Specificity,
pubmed-meshheading:6305732-T-Lymphocytes
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pubmed:year |
1983
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pubmed:articleTitle |
Interleukin 3-dependent hematopoietic progenitor cell lines.
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pubmed:publicationType |
Journal Article
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