Linked Life Data

6305690

Source:http://linkedlifedata.com/resource/pubmed/id/6305690

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-8-26
pubmed:abstractText
The effects of methylmercury (MeHg) on cytoplasmic microtubules in cultured fibroblasts and on the in vitro polymerization of microtubules were examined. MeHg caused disruption of cellular microtubules in a concentration- and time-dependent manner. Addition of the metal-chelating agent, dimercaptosuccinic acid (DMSA), both prevented and reversed the effect of MeHg. Comparisons of the cellular levels of mercury and microtubule integrity indicated that microtubules dissociated at levels higher than 0.6 microgram Hg/mg protein. In vitro polymerization was also directly inhibited by MeHg; this effect was prevented by the addition of DMSA.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0014-4827
pubmed:author
pubmed:issnType
Print
pubmed:volume
146
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-37
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Interaction of methylmercury with microtubules in cultured cells and in vitro.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.