Linked Life Data

6304103

Source:http://linkedlifedata.com/resource/pubmed/id/6304103

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-7-8
pubmed:abstractText
1 In rats anaesthetised with chloralose and pentobarbitone, frequency-dependent tachycardia and contraction of the ipsilateral inferior eyelid occurred when the intact right cervical sympathetic nerve was stimulated. 2 After successive doses of 5, 12.5 and 30 micrograms.kg-1 neostigmine sulphate (i.v.) a progressive reduction was seen in the tachycardias to low frequency stimulation (0.2 to 2 Hz) but either no effect, or an augmentation after 30 micrograms.kg-1, was evident at higher frequencies (up to 20 Hz). Atropine sulphate (i.v., 100 micrograms.kg-1) abolished the augmentatory effect of neostigmine on the high-frequency responses and offset partially the depressant effect of neostigmine on the responses to 0.2 and 0.5 Hz. By contrast, contractions of the eyelid were unaltered by neostigmine and atropine. 3 Reserpinised rats (8 mg.kg-1 i.p., 24 h earlier) were quite refractory to stimulation and remained so after neostigmine and atropine. 4 The effectiveness of neostigmine (enhancing responses) and atropine (inhibiting them) was demonstrated on endogenous acetylcholine (ACh) by measuring bradycardia to right efferent vagal stimulation, and on exogenous ACh by measuring inferior eyelid retraction in both reserpinised and control rats. These groups were equally sensitive to either ACh or noradrenaline and cocaine potentiated the tachycardia to noradrenaline in both groups. 5 Propranolol reduced the tachycardia and phentolamine the eyelid contraction induced by sympathetic nerve stimulation. 6 The findings offer no support to a theory implying an obligatory cholinergic-link in noradrenergic transmission.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0144-1795
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-20
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Absence of a cholinergic component in noradrenergic transmission in the cervical sympathetic nerve of the rat.
pubmed:publicationType
Journal Article