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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1983-7-15
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pubmed:abstractText |
Individuals with sickle cell anemia are subject to serious infections caused by a number of bacteria, including Salmonella species and Staphylococcus aureus. It has been suggested that in sickle cell anemia, extensive erythrophagocytosis by macrophages may interfere with their antibacterial function and thereby predispose to infection. As a means of investigating this possibility, we evaluated the effects of erythrocyte ingestion on the Killing of Salmonella typhimurium by peritoneal macrophages and of S. aureus by alveolar macrophages. Monolayers of rabbit macrophages were exposed to erythrocytes or latex particles immediately before and during bacterial challenge. Erythrophagocytosis markedly inhibited intracellular killing of S. typhimurium by peritoneal macrophages (bacterial survival was 181% of control) and of staphylococci by alveolar macrophages (bacterial survival was greater than 200% of control). Exposure to latex particles depressed the bactericidal activity of alveolar macrophages to a lesser degree. Next we investigated the possibility that erythrophagocytosis inhibits oxidative bactericidal mechanisms in macrophages. Hexose monophosphate shunt activity was stimulated by erythrocyte ingestion. However, zymosan-induced superoxide generation and chemiluminescence were suppressed by erythrocytes. Furthermore, a cell-free (hypoxanthine-xanthine oxidase) system for chemiluminescence generation was also depressed in the presence of erythrocytes (intact or lysate) or by purified hemoglobin. These studies reveal that erythrophagocytosis inhibits macrophage antibacterial function, probably because of interactions between erythrocyte components and reactive products of phagocyte oxygen metabolism. This host defense abnormality may predispose to bacterial infection in certain hemolytic anemias.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-1033069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-1158522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-1252075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-1259763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-13715717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-13727273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-203852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-209122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-216763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-239059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-32855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-342154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-345801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-368287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-4146087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-4153573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-4262000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-4928903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-4944120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-4951799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-4963792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-4988270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-5125261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-5323001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-5331583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-563513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-5811425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-6053819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-6254418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-6989005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-7034261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-811751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303960-999790
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
917-23
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6303960-Animals,
pubmed-meshheading:6303960-Erythrocytes,
pubmed-meshheading:6303960-Hexosephosphates,
pubmed-meshheading:6303960-Luminescent Measurements,
pubmed-meshheading:6303960-Macrophages,
pubmed-meshheading:6303960-Male,
pubmed-meshheading:6303960-Phagocytosis,
pubmed-meshheading:6303960-Rabbits,
pubmed-meshheading:6303960-Salmonella typhimurium,
pubmed-meshheading:6303960-Staphylococcus aureus,
pubmed-meshheading:6303960-Superoxides,
pubmed-meshheading:6303960-Xanthine Oxidase
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pubmed:year |
1983
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pubmed:articleTitle |
Effect of erythrocyte ingestion on macrophage antibacterial function.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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