Linked Life Data

6303578

Source:http://linkedlifedata.com/resource/pubmed/id/6303578

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1983-7-29
pubmed:abstractText
The effects of prolactin and a serum containing antiprolactin receptor antibodies on some lactogenic and mammogenic responses were investigated in nitrosomethylurea-induced mammary tumors in organ cultures. Prolactin was able to induce an increase in lactose synthetase activity, DNA synthesis, and prolactin-binding sites at moderate (i.e., physiological) concentrations of prolactin; at higher concentrations, desensitization of the tissues was observed for DNA synthesis and lactose synthetase activity, whereas the "down-regulation" of prolactin receptors occurred. Prolactin had no effect on casein synthesis. Antiprolactin receptor serum was capable of inducing an increase in lactose synthetase activity, DNA synthesis, and prolactin-binding sites, however, lower than that observed with prolactin, thus mimicking prolactin action. The antiserum did not induce any change in casein synthesis. These findings suggest that, in rat mammary tumors, as it has been observed in the normal mammary gland, the prolactin molecule is not required beyond the initial binding to its receptor for its action to be attained. It appears also that a differentiated function has lost its hormonal dependence in these tumors, although their hormonal dependence for other functions and growth is maintained.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3170-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Prolactin-like activity of antiprolactin receptor antibodies in rat mammary tumor explants.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't