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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1983-7-29
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pubmed:abstractText |
We have investigated the regression phenomenon which occurs when EBV-infected peripheral blood mononuclear cells from seropositive individuals are cultured for one month at high cell concentration and have confirmed that regression is mediated by E+ lymphocytes. When helper/inducer (Leu 3a+) and suppressor/cytotoxic (Leu 2a+) cells are separated by fluorescence-activated cell sorting from fresh peripheral blood and co-cultured with EBV-infected autologous E- mononuclear cells, regression only regularly occurs in cultures receiving suppressor/cytotoxic lymphocytes. Titration experiments show that suppressor/cytotoxic lymphocytes are more active in the regression assay that unfractionated E+ cells. When Ia+ E+ and Ia- E+ cells are separated one week after initiation of co-cultures of E+ cells and EBV-infected E- cells, both Ia+ E+ and Ia- E+ cells are active in the regression assay although regression occurs earlier in cultures receiving Ia+ E+ cells. Experiments in which NK cells are isolated using the monoclonal antibodies H25 and H366 show that NK cells do not influence the regression phenomenon in normal individuals.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-152800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-214405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-215517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-222690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-4332899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-4333982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-4348499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-4353929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-4600315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-4879667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-5242134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-6126656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-6161964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-6163816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-6170517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-6212256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-6244495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-6256660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-6277802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-6452482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6303377-6783967
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
681-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6303377-Adult,
pubmed-meshheading:6303377-Antibodies, Monoclonal,
pubmed-meshheading:6303377-Cell Separation,
pubmed-meshheading:6303377-Cells, Cultured,
pubmed-meshheading:6303377-Flow Cytometry,
pubmed-meshheading:6303377-Herpesvirus 4, Human,
pubmed-meshheading:6303377-Humans,
pubmed-meshheading:6303377-Immunologic Memory,
pubmed-meshheading:6303377-Rosette Formation,
pubmed-meshheading:6303377-T-Lymphocytes,
pubmed-meshheading:6303377-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:6303377-T-Lymphocytes, Regulatory
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pubmed:year |
1983
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pubmed:articleTitle |
Characterisation of Epstein-Barr virus-specific memory T cells from the peripheral blood of seropositive individuals.
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pubmed:publicationType |
Journal Article
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