Linked Life Data

6302576

Source:http://linkedlifedata.com/resource/pubmed/id/6302576

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-6-10
pubmed:abstractText
In order to examine the effects of blockade of the opiate-receptor during gestation and parturition, pregnant rats were implanted with subcutaneous minipumps, loaded with either naloxone (100 or 30 mg/ml) or saline, released at a constant rate for 7 days. It was found that neonatal mortality was significantly increased in the group that received naloxone 0.1 mg/h from day 17 of pregnancy, compared to saline controls. Body weight increase was slightly retarded by administration of naloxone 0.03 mg/h, starting day 17. At the age of 40 days, the groups exposed to naloxone 0.03 mg/h during late gestation showed a significant analgetic response to morphine 5 mg/kg, in contrast to saline controls, when tested with the hot-plate technique. The results suggest a role for endorphins during parturition and development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
323-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Prenatal naloxone affects survival and morphine sensitivity of rat offspring.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't