Linked Life Data

6302551

Source:http://linkedlifedata.com/resource/pubmed/id/6302551

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-6-10
pubmed:abstractText
Opiate receptor binding, using [3H]naloxone, was measured in spinal cords of fetuses and postnatal offspring of pregnant rats, injected with morphine or saline or pair-fed with morphine-injected animals during the last half of gestation. Binding was decreased in the spinal cord in morphine-treated offspring on the 21st day of gestation and remained depressed for 30 days postnatally. However, by 60 days postnatally the binding in the spinal cord was greater in morphine-treated offspring than in controls. The decrease in binding on the spinal cord was greater in morphine-treated offspring than in controls. The decrease in binding on the 21st day of gestation appears to be due to a decrease in the number of binding sites, with no change in binding affinity. The KD for [3H]naloxone binding in spinal cords of saline-injected and pair-fed animals decreased by about 50% between day 21 of gestation and 60 days postnatally. The increase in binding in spinal cords of adults reflects a change in the number of binding sites as well as a decrease in [3H]naloxone affinity in the morphine-treated offspring.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0028-3908
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Changes in [3H]naloxone binding in spinal cord of rats treated prenatally with morphine.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.