Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1983-6-17
|
| pubmed:abstractText |
Tumor extracts from 9 patients with medullary thyroid carcinoma were studied to determine if multiple forms of immunoreactive calcitonin existed within the tumors. Calcitonin was extracted from the tumors with 0.1 N formic acid and the extracts were evaluated by gel filtration on columns of Bio-Gel P-10 and radioimmunoassay of the fractions obtained. Serum calcitonin concentrations were high enough in 3 patients to allow for similar evaluation. Four immunoreactive peaks of calcitonin were found after chromatography of the tumor extracts. Three of the peaks eluted earlier than monomer human calcitonin. 6 tumor extracts contained all four immunoreactive peaks while 3 had only two. In 2 patients four immunoreactive peaks of calcitonin were found in both the serum and the tumor extracts while 1 patient had three peaks in the serum but only two peaks were detected in the tumor extract.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0378-0392
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
292-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1982
|
| pubmed:articleTitle |
Heterogeneity of immunoreactive calcitonin in extracts of medullary thyroid carcinoma.
|
| pubmed:publicationType |
Journal Article
|