Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-6-10
pubmed:abstractText
In an attempt to define the nature of the difference in the susceptibility of C57BL/6 (resistant) and A/J (susceptible) mice to herpes simplex virus type 1, we initiated a study of virus progression through the nervous system. After inoculation of virus in a rear footpad, C57BL/6 mice were found to be more than 500-fold more resistant, but resistance did not extend to pseudorabies virus. In additional investigations, it was found that the virus was selectively restricted at the level of spinal ganglia in C57BL/6 mice. No intrinsic difference in the ability of this tissue from either mouse strain to replicate virus was found. However, by 4 days after infection, morphological investigations indicated that a mononuclear cell infiltrate was present surrounding infected neurons and satellite cells both earlier and in greater numbers in the ganglia of C57BL/6 mice. Immunohistochemical methods showed that most of these cells did not express Thy 1.2 antigen, but the vast majority bore immunoglobulin G. The mechanism by which these infiltrating cells could restrict virus spread is discussed.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6302004-109389, http://linkedlifedata.com/resource/pubmed/commentcorrection/6302004-169103, http://linkedlifedata.com/resource/pubmed/commentcorrection/6302004-171586, http://linkedlifedata.com/resource/pubmed/commentcorrection/6302004-203530, http://linkedlifedata.com/resource/pubmed/commentcorrection/6302004-203636, http://linkedlifedata.com/resource/pubmed/commentcorrection/6302004-219668, http://linkedlifedata.com/resource/pubmed/commentcorrection/6302004-314862, http://linkedlifedata.com/resource/pubmed/commentcorrection/6302004-398327, http://linkedlifedata.com/resource/pubmed/commentcorrection/6302004-4348966, http://linkedlifedata.com/resource/pubmed/commentcorrection/6302004-5786178, http://linkedlifedata.com/resource/pubmed/commentcorrection/6302004-6168735, http://linkedlifedata.com/resource/pubmed/commentcorrection/6302004-6249746, http://linkedlifedata.com/resource/pubmed/commentcorrection/6302004-6252286, http://linkedlifedata.com/resource/pubmed/commentcorrection/6302004-6254873
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
752-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Restricted replication of herpes simplex virus in spinal ganglia of resistant mice is accompanied by an early infiltration of immunoglobulin G-bearing cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.