|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1983-5-5
|
|
pubmed:abstractText |
A variety of tumor promoters such as the phorbol esters were found to be capable of inducing the viral cycle in cell lines latently infected with Epstein-Barr virus (EBV). We tested two classes of new tumor promoters; indole alkaloids and polyacetates, for their ability to induce the synthesis of the Epstein-Barr virus determined early antigen (EA) complex. Teleocidin and lyngbyatoxin A are indole alkaloids. Aplysiatoxin and debromoaplysiatoxin are polyacetates. Of these four tumor promoters all but debromoaplysiatoxin induced the synthesis of the EA complex. However, in combination with 3 mM n-butyrate, all four induced EA synthesis. The potent tumor promoters teleocidin, lyngbyatoxin A and aplysiatoxin induced maximal synthesis of EA at the concentration of 5 to 10 ng/ml, whereas the weak tumor promoter debromoaplysiatoxin required a concentration of 250 ng/ml to achieve maximal induction. Phorbol esters induce quick morphological changes and aggregation of human blood lymphocytes. The latter phenomenon has been interpreted as the expression of a "cell binding phenotype" (Patarroyo et al., in press). We showed that all four promoters induced aggregation of human lymphocytes at similar concentrations. The induction seemed to be a common effect which could be induced by both strong and weak tumor promoters.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Epstein-Barr virus early antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Lactones,
http://linkedlifedata.com/resource/pubmed/chemical/Lyngbya Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Marine Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Phorbol Esters,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug,
http://linkedlifedata.com/resource/pubmed/chemical/Unc-13 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/aplysiatoxin,
http://linkedlifedata.com/resource/pubmed/chemical/debromoaplysiatoxin,
http://linkedlifedata.com/resource/pubmed/chemical/lyngbyatoxin A,
http://linkedlifedata.com/resource/pubmed/chemical/phorbol ester receptor,
http://linkedlifedata.com/resource/pubmed/chemical/teleocidin
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0020-7136
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
31
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
7-11
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6299973-Alkaloids,
pubmed-meshheading:6299973-Antigens, Viral,
pubmed-meshheading:6299973-Caenorhabditis elegans Proteins,
pubmed-meshheading:6299973-Carcinogens,
pubmed-meshheading:6299973-Cell Aggregation,
pubmed-meshheading:6299973-Herpesvirus 4, Human,
pubmed-meshheading:6299973-Humans,
pubmed-meshheading:6299973-Lactones,
pubmed-meshheading:6299973-Lymphocytes,
pubmed-meshheading:6299973-Lyngbya Toxins,
pubmed-meshheading:6299973-Marine Toxins,
pubmed-meshheading:6299973-Phorbol Esters,
pubmed-meshheading:6299973-Protein Kinase C,
pubmed-meshheading:6299973-Receptors, Cell Surface,
pubmed-meshheading:6299973-Receptors, Drug,
pubmed-meshheading:6299973-Virus Activation
|
|
pubmed:year |
1983
|
|
pubmed:articleTitle |
Activation of the EBV-cycle and aggregation of human blood lymphocytes by the tumor promoters teleocidin, lyngbyatoxin A, aplysiatoxin and debromoaplysiatoxin.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
