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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1983-4-21
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pubmed:abstractText |
Field stimulation of the isolated main bronchi of the guinea-pig results in a rapid contraction followed by a sustained contractile response. Tetrodotoxin abolished these effects. The first phase was strongly inhibited by hyoscine, indicating that it was mediated mainly by excitation of cholinergic nerves. The lasting contraction was abolished by capsaicin tachyphylaxis but it was resistant to the effects of hyoscine, hexamethonium or physostigmine. It is suggested that capsaicin-sensitive non-cholinergic nerves have major excitatory effect on the guinea-pig bronchial smooth muscle and there is also evidence for their influence on the trachea.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0304-3940
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
31
|
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
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pubmed:pagination |
247-51
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:6298673-Animals,
pubmed-meshheading:6298673-Bronchi,
pubmed-meshheading:6298673-Capsaicin,
pubmed-meshheading:6298673-Carbachol,
pubmed-meshheading:6298673-Fatty Acids, Unsaturated,
pubmed-meshheading:6298673-Female,
pubmed-meshheading:6298673-Guinea Pigs,
pubmed-meshheading:6298673-Male,
pubmed-meshheading:6298673-Muscle, Smooth,
pubmed-meshheading:6298673-Muscle Contraction,
pubmed-meshheading:6298673-Receptors, Cholinergic,
pubmed-meshheading:6298673-Scopolamine Hydrobromide,
pubmed-meshheading:6298673-Synaptic Transmission,
pubmed-meshheading:6298673-Trachea
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pubmed:year |
1982
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pubmed:articleTitle |
Capsaicin-sensitive non-cholinergic excitatory innervation of the guinea-pig tracheobronchial smooth muscle.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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